Laboratory of Dr. Binhai Zheng



Currently Recruiting (April 2017):

We are currently recruiting new lab members, including both postdoctoral and/or predoctoral fellows. Recent projects focused on a MAP3K pathway in neuronal and glial responses to injury and age-dependent changes in neuronal responses to injury. Molecular biology, in vitro neuronal culture, in vivo spinal cord injury models and optical imaging are some of the tools used in our projects. Please contact Dr. Binhai Zheng for further information (binhai@ucsd.edu).


News:

The 2017 San Diego Spinal Cord Injury and Repair Symposium, sponsorded by the Paralyzed Veterans of America, was held on April 11 Tuesday at the UC San Diego Faculty Club. Guest speakers Drs. Grégoire Courtine, Aileen Anderson, Leif Havton, Scott Whittemore, local faculty members Drs. Justin Brown, Yishi Jin, Yimin Zou, Mark Tuszynski, Binhai Zheng, and Sharp HealthCare physician Dr. Jerome Stenehjem spoke at the symposium. PVA national director Mr. Jim Russell spoke on behalf of attendees from the PVA. See pictures from the symposium taken by Steven Shelden (PVA).

Our paper on MAP3K13 (Chen et al.) in collaboration with Dr. Yishi Jin and Dr. Larry Holzman has been published by Scientific Reports.

Our paper with Dr. Wolfram Tetzlaff's lab at the University of British Columbia on the impact of age on axon regeneration after spinal cord injury is published in Cell Reporrts.

News stories on this paper:

UCSD: Aging diminishes spinal cord regeneration after injury

EurekAlert!: Aging diminishes spinal cord regeneration after injury

2016 UCSD Neural Injury and Regeneration Symposium was held on October 17, 2016. Supported by a grant from the Paralyzed Veterans of America. Keynote address was delivered by UCSD neurosurgeon Dr. Joseph Ciacci. Local PVA chapter Government Relations Director Mr. Wayne Landon attended the meeting and addressed the attendees to encourage dialogues between the researchers and the spinal cord injury community. See symposium agenda and pictures.

The 2015 UCSD - HeadNorth Neural Injury and Regeneration Symposium was held on June 8, 2015. Local Neurosurgeon Dr. Justin Brown and ICORD Director Dr. Wolfram Tetzlaff gave talks in addition to presentations by local neural regeneration labs. See symposium website for program and pictures. 

May 6-7, 2015, Wings for Life Scientific Meeting was held in Salzburg, Austria. See group photo.

April 30, 2015 See news from UC Health: Spinal cord axon injury location determines neuron’s regenerative fate 

which was a story on our in vivo imaging paper in Neuron (Lorenzana et al): A surviving intact branch stabilizes remaning axon architechture after injury as revealed by in vivo imaging in the mouse spinal cord.

April 21, 2015 See our Journal of Neuroscience paper on the interplay between neuron-intrinsic and extrinsic control of CNS axon repair (Geoffroy et al): Effects of PTEN and Nogo codeletion on corticospinal axon sprouting and regeneration in mice.

The 2014 UCSD - HeadNorth Neural Injury and Regeneration Symposium was held on Wednesday June 4, 2014 (1:30 - 5 pm, CNCB auditorium)n that serves thMembers of local neural regeneration research labs presented their research, followed by keynote address by Dr. Reggie Edgerton from UCLA.  HeadNorth is a local non-profit organization that serves the need of people impacted by spinal cord injury. See meeting agenda and pictures from the meeting.

5/21/2014 Our lab was awarded a gift from the Christopher and Dana Reeve Foundation in suppport of our spinal cord research. Peter T. Wilderotter, President and CEO of the Foundation, personally presented the gift to Dr. Zheng at the Wings for Life meeting in Salzburg, Austria. Thank you, CDRF!

Read this blog about our recent perspective on axon sprouting in developing spinal cord injury treatment published in Neural Regeneration Research.

The 2013 UCSD - HeadNorth Neural Injury and Regeneration Symposium

Science Daily story on our collaborative study with Dr. Zhigang He on PTEN in spinal axon regeneration

Science Daily story on our study of myelin inhibitors in axon growth and regeneration


To see a video produced by UCSD School of Medicine on our myelin inhibitor study, click here


About the Zheng Research Group at UCSD

We are a group of scientists in the Department of Neurosciences at the University of California San Diego. Our lab uses genetically modified mice to study why axons in the central nervous system (the brain and the spinal cord) have such a limited ability to regenerate following injury. The insight gained from our research is directly relevant to the design of therapeutic interventions for spinal cord injury, white matter stroke and certain neurodegenerative disorders. In addition, we are developing ways to genetically engineer human pluripotent stem cells to study their differentiation potential and to model neurological conditions. We collaborate with other regeneration researchers on campus including Dr. Mark Tuszynski and Dr. Yishi Jin.

Design by John Widjaja